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The N-acetyl capping at the N-terminus and C-terminal amidation protect the peptide from exopeptidase degradation aminopeptidases at the N-terminus and carboxypeptidases at the C-terminus extending its biological half-life compared to unmodified Epitalon
Citicoline treatment was found to be associated with higher scores on cognitive and functional evaluation scales when compared to baseline measurements
Mild skin irritation (redness, burning sensation) when using high concentrations
Its a different animal together
Systematic post-market surveillance and long-term safety studies would address these knowledge gaps as clinical use potentially expands
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