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Measurable weight loss begins within 4 to 8 weeks as the dose increases
Venlafaxine should be discontinued before initiating treatment with the MAOI (see CONTRAINDICATIONS and DOSAGE AND ADMINISTRATION)
Yang Y, Lv J, Jiang S, Ma Z, Wang D, Hu W, Deng C, Fan C, Di S, Sun Y, et al
When you stop, the same half-life applies: expect ~45 weeks for most clearance, with residual amounts possibly up to ~7 weeks, consistent with patient guidance such as Drugs.coms overview
Serious Adverse Events and Discontinuation Signals In TRANSCEND-T2D-1, Lilly reported adverse-event discontinuation rates of 2.2%, 4.5%, and 5.1% with retatrutide 4 mg, 9 mg, and 12 mg, compared with 0.0% with placebo [9]
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