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Dushay J, Chui PC, Gopalakrishnan GS et al (2010) Increased fibroblast growth factor 21 in obesity and nonalcoholic fatty liver disease

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Interestingly, in elderly subjects with normal BP, acute elevations of plasma insulin during hyperinsulinemic/euglycemic clamp caused vasoconstriction, accompanied by a blunted increase in norepinephrine and heart rate, as compared to young individuals, while no changes in BP were observed in either group

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