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In a 2022 metanalysis [89] of previous randomized controlled trials, 20 papers from 19 randomized placebo-controlled trials were included, comprising a total sample size of 2062
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A deficiency can, therefore, lead not only to the central nervous system manifestations seen in Wernicke encephalopathy but also to peripheral sensorimotor neuropathy, characterized by weakness, numbness, and pain in the extremities
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