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Exendin-4 had anti-inflammatory properties by activating adenylate cyclase (cAMP) in macrophages, which inhibited the expression of TNF- (tumor necrosis factor ) and MCP-1inflammatory and atherogenic mediators
All the authors participated in data analysis and reviewed and approved the final manuscript
Rationally designed combination regimens that simultaneously target tumor cells and the TME offer a transformative opportunity to improve outcomes in patients with therapy-resistant malignancies
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Insulin in the brain: sources, localization and functions
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