Bariatric surgery volumes are declining for the first time in recorded history as GLP-1 pharmacotherapy outcomes approach surgical efficacy thresholds
The consensus statement does suggest, however, that DPP-4 inhibitors may be appropriate in select populations based on concerns associated with weight gain and hypoglycemia, similar to the AACE and ACE recommendations
Its most distinctive physicochemical property is hydrolytic stability at low pH, unlike almost every peptide of comparable length, BPC-157 resists degradation in human gastric juice, a characteristic emphasised throughout the published work of Sikiric and colleagues (Curr Med Chem, 2012)
Since it is an aider in the transport of fatty acids to the mitochondria, it can also increase the oxidation of fat and hence promote even more loss of fats, especially when combined with regular exercise
BPC-157 is often associated with local tissue repair, while TB-500 is commonly viewed as supporting broader recovery processes throughout the body