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Those who took GLP-1s for less than 18 months before discontinuing saw no significant risk reduction compared to the group on sulfonylureas at the end of the trial
Its significance in anaesthetic practice
However, in randomized clinical trials in type 2 diabetes, semaglutide resulted in up to 3 times greater weight loss compared with other GLP-1RAs and up to twice as much in patients with obesity, approaching 15 kg (35)
"Without Needles" - Factually accurate as far as it goes
To put that into perspective, the average weight loss with Wegovy (semaglutide 2.4 mg) is around 17.5% over 68 weeks, and with Mounjaro (tirzepatide 15 mg), around 20% over 72 weeks
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