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The neuroinflammatory etiopathology of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Do not double your dose, as this could lead to unintended side effects

For most people, expect about one to two weeks of noticeable effects, with the exact timing shaped by your levels, metabolism, diet, absorption, and age

That includes people with abdominal weight gain, prediabetes or type 2 diabetes, elevated fasting insulin, high triglycerides, low HDL, nonalcoholic fatty liver disease, PCOS, or an elevated inflammatory marker in the setting of obesity

Furthermore, genetic variations or deficiencies in OCT2 can influence its phenotypic activity, predisposition to toxicity, and response to drug treatments