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Irregularidades na produo de citocinas tambm esto associadas ao distrbio lipdico, sendo a principal citocina envolvida o fator de necrose tumoral alfa (TNF-a) que se encontra elevado na AIDS e provoca aumento de triglicrides pela inibio da lipase lipoprotica, diminuindo a depurao dos quilomcrons e VLDL plasmticos 6

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