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Gruppen EG, Garcia E, Connelly MA, Jeyarajah EJ, Otvos JD, Bakker SJL, Dullaart RPF

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Disruption of PKA signaling is linked to altered fat and glucose metabolism in obesity

Published pre-clinical studies have used FOXO4-DRI to demonstrate that selective elimination of senescent cells in aged mouse models can improve a range of tissue function parameters including fitness, fur density, renal function, and liver function establishing the broader research principle that senescent cell burden contributes meaningfully to ageing tissue dysfunction and that its targeted reduction produces measurable functional benefits in experimental models

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