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The common allele is cytoprotective against the toxic effects of chemotherapeutics, whereas the functionally less competent allele is thought to increase the toxicity of anticancerogenic drugs in patients with this gene variant due to decreased metabolic activity of impaired enzyme
the second is that the long-term stimuli-increased secretory activity leads to a depletion of the releasable insulin of -cells 31
If youre sensitive to it, under 18, or diagnosed with conditions exacerbated by caffeine, like anxiety, insomnia, rapid heart rate, or acid reflux, you should be even more cautious
Curr Dreg Metab 17(6):573581 Williams AB, Schumacher B (2016) p53 in the DNA-damage-repair process
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