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SGLT-2 inhibitors: the gap seems to be leveling off

They were disappointed by a non-significant 0.5% reduction in A1c among patients taking the drug, compared to a 0.3% reduction in the placebo group, all of whom had poorly controlled A1c levels above 8%

O'Malley D, Quigley EM, Dinan TG, Cryan JF

Taken alongside the reported increases in regional CBF discussed previously, increased expression of neurotrophic factors in response to RT may facilitate neurogenesis and synaptic plasticity in the hippocampus and its subfields