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We confirmed both in vitro and in vivo that specific combination of ligands of different transporters, especially alanine and glutathione, is more efficient than single ligands to facilitate the penetration of nanocarrierss across the BBB [24, 32, 33, 42]
Both have been studied in overlapping contexts (fibroblast proliferation in cited models, tendon repair, muscle injury), but through different enough mechanisms that combination research is scientifically justified
Li X, Meng F, Li H, Hua X, Wu L, Yuan X
Funding This work was supported by National Science Centre in Poland, grant number 2014/15/B/NZ7/00893