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Metabolism The metabolism of common GLP-1 RAs varies across agents: Exenatide undergoes hydrolysis in the kidneys and liver, producing smaller inactive peptides excreted via the kidneys (23)

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For decades, this trend seemed to be insurmountable contributing to an obesity pandemic that places an enormous burden on our collective health due to obesitys association with various conditions including type 2 diabetes, cardiovascular disease, metabolic dysfunction-associated steatotic liver disease (MASLD), and certain types of cancer to name just a few [2]