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These findings substantially enhance our understanding of agent-specific and patient-related characteristics affecting the use of GLP-1RAs in a major population encountered by gastroenterologists in clinics

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This issue came to the fore in early 2024 when the UK MHRA issued a National Patient Safety Alert triggered by global supply issues for certain GLP-1 drugs, advising healthcare professionals to conserve existing stock for patients with Type 2 diabetes.6,7 The implementation of such measures ensures that the critical priority of patient needs continues to be met, while also avoiding patients seeking what the WHO describes as falsified or substandard versions of these medicines through unregulated outlets on the internet.8 Looking to the future, demand for GLP-1 drugs is expected to remain high as healthcare systems look to manage obesity and diabetes among an ageing population