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This piece in 1993 also provided new insights into the biology of exendin, namely that exendin-4 was a full agonist of the human GLP-1 receptor, which Mojsov argues was crucial to convincing Amylin to develop exendin as a drug for diabetes (see below)
Furthermore this efficacy-to-tolerability ratio appears to be significantly lower for tirzepatide than semaglutide
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