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Similarly, cardiovascular benefits independent of GLP-1R activation have also been demonstrated [38]
In a small open-label trial of exenatide in people with clozapine-associated obesity (BMI 3045 kg/m 2 ), those on exenatide had about 10 pounds more weight loss than placebo at 24 weeks (Siskind D et al, J Psychiatr Res 2020;124:912)
Starting with a low dose, maintaining hydration, and eating small meals can reduce mechanical stress on your colon while taking semaglutide
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