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317 Researchers have found that Fer-1 binds to 15LOX/phosphatidylethanolamine binding protein-1 (PEBP1) complex, suppressing the generation of peroxidized eicosatetraenoyl-phosphatidylethanolamine (ETE-PE) and protecting against ferroptosis

Methyltransferase 3 (METTL3)-mediated N6-methyladenosine (m6A) modification is another cancer-promoting mechanism that protects cells from ferroptosis by increasing PBX1 mRNA stability, which in turn increases GCH1 expression and inhibits ferroptosis through the GCH1-BH4 axis [81]

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