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200,201,202 Orteronel is a nonsteroidal selective inhibitor of 17,20-lyase, while galeterone has multiple mechanisms of action, including CYP17A1 inhibition, AR antagonism, and a reduction in both full-length AR and AR-V7 levels

Souza-Moreira TM, Navarrete C, Chen X, Zanelli CF, Valentini SR, Furlan M, Nielsen J, Krivoruchko A