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Crystallographic study and mutagenesis analysis identify the structural and functional defect of one common mutant (Canton, R459L)
D., Sampson, J
doi: 10.1016/j.mec.2020.e00149 125 HichriI.BarrieuF.BogsJ.KappelC.DelrotS.LauvergeatV
Resulting deficits include impairments in episodic memory, poor spatial navigation, reduced neurogenesis and synaptogenesis, as well as social avoidance
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