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The installed glycan is the O-mannose disaccharide Manα1-2Man
2-Azidoethyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside
/ CMP-N-acetylneuraminic acid / CMP-Neu5Ac
followed by cleavage of the α-glycosidic bond by α-L-iduronidase (IDUA) to release 4-methylumbelliferone
2-Azidoethyl 2-(Acetylamino)-2-deoxy-α-D-galactopyranoside
AG152015: β-D-GalNAc-Pentyl-Carboxylic Acid (Peracetate) Pack Size:25 mg The installed glycan is theC20H31NO11 461. 46 A peracetylated D N acetylgalactosamine (GalNAc) ligand equipped with a terminal carboxylic acid through a pentyl spacer, with the sugar hydroxyl groups protected as acetate esters. The peracetate groups increase lipophilicity to facilitate cell membrane permeability. The carboxylic acid can be activated to NHS, sulfo NHS, or pentafluorophenyl (PFP) esters and reacted with amine functionalized platforms or lysine residues on
