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Administration: Administer via subcutaneous injection, topical application in formulations, or direct addition to cell culture media in preclinical models
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Caution is warranted because animal findings do not reliably map onto what happens in people
In the IMPACT trial, pemvidutide achieved mean weight losses of 4.8% and 5.8% with 1.2 and 1.8 mg doses respectively at 24 weeks, compared to 0.5% with placebo, with weight loss curves showing no evidence of plateauing, suggesting continued benefit with longer treatment [49-51]
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