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Semaglutide is not indicated for use in patients with type 1 diabetes
This is a perception or severity issue, not a safety concern
In a recent study, tirzepatide achieved greater reductions in HbA1c levels compared to other commonly used diabetes medications
The introduction of the R17 Cagri- E14 Cagri intra-peptide ionic lock energetically favours the formation of a predominant bypass conformation at the CTR, which, together with the P37 substitution and the effects induced by the N-terminal acylation, likely underlies its improved potency over rAmy at this receptor
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