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Most patients who experience chills during semaglutide initiation notice symptom resolution within 37 days as their body adapts to the medication

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DOI: 10.1056/NEJMoa2416394 Hannon TS, Chao LC, Barrientos-Prez M, et al

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Many people labelled as non-responders to GLP-1 receptor agonists such as semaglutide do not take the medication correctly or discontinue treatment before adequate therapeutic effect can be achieved

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