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(iv) patients received sorafenib as a first-line treatment between January 1, 2023, and January 1, 2025, and demonstrated a therapeutic response after a minimum of three months of treatment, confirmed by imaging changes on either CT or MRI and/or a decrease in serum -fetoprotein (AFP) levels compared to previous measurements [34],(v) patients received regorafenib as a second line treatment after showing unresponsive from the sorafenib after a minimum of three months of treatment, confirmed by no imaging changes on either CT or MRI and/or an increase in serum -fetoprotein (AFP) levels compared to prior clinical measurement [35]
Presented for research literature review only Rangubpit W et al
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Arnhold and Malle, 2022
Indeed, the deletion of ciaR mutant lead to a reduced HtrA expression and, consequently, to an increased susceptibility to external H 2 O 2 similar to that of the htrA mutant
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