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The success of clinical trials with exenatide and liraglutide sparked growing interest in therapies based on GLP-1
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The core pharmacophore of alpha-MSH resides in the central tetrapeptide sequence His-Phe-Arg-Trp (positions 6-9), which is conserved in both Melanotan II and PT-141
They started with a natural hormone called amylin and made specific changes to its structure to make it more effective and last longer in the body
While early data are promising, they are not yet sufficient to support routine use in substance use disorders
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