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The STEP clinical trial program demonstrated that semaglutide consistently produced 10.9% to 14.9% weight loss across diverse patient populations, with 83.5% of participants achieving clinically meaningful weight loss of 5% or more
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However, these adjusted thresholds have not been formally incorporated into FDA labeling for GLP-1 medications, creating a significant gap where Asian patients may have clear metabolic indications for treatment but fail to meet the standard BMI criteria
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