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Kaste SC, Chesney RW, Hudson MM, Lustig RH, Rose SR, Carbone LD: Bone mineral density during and after therapy of childhood cancer: an increasing population with multiple risk factors for impaired bone health

Documented benefits include improved insulin sensitivity in type 2 diabetes (20), reduced inflammatory cytokines and short-term mortality in sepsis (21), and ameliorated cardiac fibrosis in experimental heart failure models (22)

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Small molecule oral GLP-1 receptor agonists are currently in development, and we introduce how these chemicals have addressed the challenge posed by interactions with the large extracellular ligand binding domain of the GLP-1 receptor