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This benefit appeared independent of weight loss, suggesting direct cardiovascular protective effects from GLP-1 receptor activation

A 2019 analysis from the Hispanic Community Health Study / Study of Latinos (HCHS/SOL, N=16,415) found that HOMA-IR values were significantly elevated even among participants with normal BMI, suggesting a metabolic phenotype that is partly independent of adiposity [6]

Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility [PMID: 33543238] Laboratory literature summary: Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility

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Semaglutida es un anlogo acilado selectivo de GLP-1R