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The first is metabolic symbiosis between tumor cells: hypoxic cells export lactate and protons via MCT4, while normoxic neighbors import it via MCT1 for oxidative phosphorylation, thereby optimizing intra-tumoral resource utilization [45]
When validated in randomized clinical trials, only a few drugs have shown efficacy on NASH liver histology and/or fibrosis
Lysosomal acid lipase deficiency unmasked in two children with nonalcoholic fatty liver disease
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