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Telogen effluvium is already associated with weight loss, and the rapid weight loss associated with GLP-1 use could also lead to non-scarring alopecia

For patients with Hashimoto's thyroiditis taking levothyroxine replacement therapy, an important consideration is tirzepatide's effect on gastric emptying, which may impact the absorption of oral medications

Another cohort study of the same TriNetX database found that 193 IIH patients taking tirzepatide had a reduction in BMI of 1.147 mm/kg 2 greater than 193 controls (18)

This quiz covers the important concepts and principles used to guide initial optimization and SAR in the absence of a ligand-bound structure