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Accurate dosage and administration are vital for achieving the best therapeutic outcomes and minimizing the risk of hypersensitivity reactions
Genetic Factors in GLP-1 Tolerance and Digestive Side Effects Individual variations in how your body processes and responds to GLP-1 medications are partly determined by your genetic makeup, particularly genes controlling GLP-1 receptor function, appetite signaling, and gastrointestinal motility
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Nevertheless, the overall trend suggests a reduction in basal insulin dose by up to 17% and a decrease in prandial insulin dose by up to 30% in addition of GLP-1RA to insulin therapy, especially with long-acting forms [32]
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