Continuous use beyond 16 weeks causes receptor downregulation, reducing GH pulse amplitude by 2040%
Kenakin says this is always a hazard: If you have an oral drug, the organ that receives the highest dose is the liver 50% of all drugs fail on liver toxicity, he says
The insidious disease progression presents substantial clinical challenges, as approximately 2040% of NAFLD patients may develop non-alcoholic steatohepatitis (NASH) over several years (1, 2), which can subsequently advance to liver fibrosis and HCC (3)
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