ROS mutate genes involved in various metabolic pathways throughout the body and prevent the detoxification and excretion of toxic waste
Conclusion Clinical trials show that GLP1 medications can produce meaningful weight loss, averaging 10 to 22% of body weight depending on the medication and dose
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Incretin mimetics have demonstrated safety and efficacy in advanced kidney disease, however multiple studies have shown that use of GLP1-RA have shown improvements in glycemic control, body weight reductions, improved beta cell function, and decreased incidence hypoglycemia as compared to DPP4i in a general diabetes population 26,27,28,29,30,31 , effects which might explain the reduction of acute healthcare utilization observed in this study of patients with CKD treated with GLP1-RA as compared to DPP4i