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Helpful if your target dose is tiny (e.g., 50100 mcg) and youd rather pull to tick 48 instead of 12
Hydrocarbon stapling also enhances the pharmacological performance of peptide drugs by dramatically improving target affinity, resistance to proteolysis, cell permeability, and in vivo pharmacokinetics 33,34
Laskowitz, D
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10.1016/0896-6273(92)90292-L 8 BhangooS
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