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Podrini confirmed the defective glucose metabolism and characterized other altered metabolic pathways in mouse kidney without Pkd1 such as increased pentose phosphate pathway (PPP), glutamine uptake and decreased TCA cycle and fatty acid oxidation (FAO) (Podrini et al., 2020)
Quick answer: Semax targets BDNF and dopamine signaling for focus, Selank works on GABA and the immune-peptide system for calm without sedation, and Dihexa is a preclinical compound studied for synapse formation
or atrial fibrillation
So far most of the trials in this area have been small and led by academic investigators
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