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Similar to scrapie, -synuclein pathology spreads in the peripheral and enteric nervous systems, then to CNS, whereas Alzheimers tau pathology propagates within the CNS only, beginning in the brainstem then involving cortical areas in a characteristic pattern (De La-Rocque et al., 2021)
Another strategy to alleviate disease-causing effects of autoreactive IgG is to block activating FcRs, thereby preventing pathological IgG-mediated activation of FcR-expressing immune cells
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Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
Eight members voted in favor of recommending the substances for the list, six voted against, and one abstained
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