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Primary side effects are gastrointestinal (nausea, vomiting)

On receipt, store sealed vials in a refrigerator (2-8C) for short-term holding or a freezer (-20C) for extended storage, protected from light and moisture

The sealed vacuum packaging provides oxidative protection during this window

We then treated new NT2-N cells with positive (medication cocktail) control, negative control (vehicle), and 960 off-patent compounds from the Prestwick library ( Based on the changes in gene expression, a similarity score for each drug relative to the medication cocktail was calculated

Although K48-linked ubiquitination is the canonical signal for proteasomal degradation, the UPS exhibits remarkable versatility through alternative ubiquitin linkages and chain architectures (Fig