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1 The cycle of depletion

Compound Receptors Peak trial weight loss Lean mass as share of loss Semaglutide (Ozempic/Wegovy) GLP-1 ~14.9% (STEP-1, 68 wk) ~39% Tirzepatide (Mounjaro/Zepbound) GLP-1 + GIP ~20.9% (SURMOUNT-1, 72 wk) ~25-40% Retatrutide GLP-1 + GIP + GCGR ~24.2% (Phase 2, 48 wk) Comparable class range Best for understanding the takeaway: the percentage of loss that is lean mass is roughly constant across the class

Superimposing a tonic pharmacological brake on top of this feedback system creates competing signals, and it would be unsurprising if intestinal feedback partially normalized emptying over time even while the drug is present

Research also suggests significant benefits for gut health, inflammatory modulation, and angiogenesis

It is not approved for any medical use in the UK