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Also, the following risk factors can increase the chance of developing vitamin B-12 deficiency: Alcohol abuse Smoking Certain prescription medications, including antacids and some type 2 diabetes drugs Having an endocrine-related autoimmune disorder, such as diabetes or a thyroid disorder Eating a vegetarian or vegan diet Certain gastrointestinal disorders, such as crohns disease Gastric bypass or the removal of parts of the stomach Aging Benefits of B-12 Shots There are several reasons to consider getting a B-12 shot, including: Reduced risk of vitamin B-12 deficiency and associated complications The most obvious benefit of receiving vitamin B-12 shots is treating a vitamin B-12 deficiency and avoiding its associated symptoms

[1] [2] Increasing levels of CD38, a membrane-bound NADase that destroys both NAD+ and its precursor nicotinamide mononucleotide, are thought to be the cause of the age-related decline in NAD+ levels, according to a 2016 study in mice, which exhibit age-related declines in NAD+ levels similar to those seen in humans

For those specifically concerned about the side-effect burden of older GHRPs, ipamorelin's selectivity is its defining advantage