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The first of these drugs, exenatide, was approved by the FDA in 2005
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Modern translational frameworks emphasize combination therapy, biomarker-guided dosing, and behavioral stratification, all of which may improve the therapeutic index of appetite-regulating peptides
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252 The NICD then translocates into the nucleus, where it forms a transcriptional complex with RBP-J and Mastermind-like (MAML) coactivators, activating downstream targets such as Hes, Hey, c-Myc, and Bcl-2
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