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Its prevalence is between 15% and 85% of patients with ALS [84]
Moreover, UA-induced inflammation and oxidative stress can also trigger endoplasmic reticulum (ER) stress, decreased nitric oxide bioavailability and produce peroxynitrite (ONOO-), a very powerful radical, which contributing to cellular dysfunction and apoptosis
Consequently, therapeutic strategies that either inhibit or activate glucagon are being actively researched in clinical settings [104]
Thawabteh, A
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