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More importantly, hyperactive ribosome biogenesis can trigger the concomitant activation of tumor-related signaling pathways
Another common preclinical model involves using chemically induced damage, such as oxidative stress or inflammation, to test the peptides potential in mitigating cellular damage
If the pH is 2 units below the pKa, the HH equation becomes -2 = log A/HA, or \)
Microtubule-disrupting agents: Auristatin, Maytansinoid, and Tubulysin Disruption of microtubule-facilitated movement and segregation of chromosomes during mitosis induces mitotic arrest and apoptosis in rapidly dividing cancer cells 10,12
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