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Without a sponsor willing to invest in US trials, approval cannot occur

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Patients frequently report an energy change in the first day or two, which is most plausibly B12 in deficient patients, and expectation in everyone else

A broader narrative review published in 2024 also concluded that IV glutathione is associated with serious safety concerns including anaphylaxis and hepatotoxicity , and stressed that there is insufficient evidence to recommend IV use for cosmetic skin lightening

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